Article
Genetic and expression analysis of SNPs in the human deoxyribonuclease II: SNPs in the promoter region reduce its in vivo activity through decreased promoter activity.
Electrophoresis - 1 Sept 2012
Kimura-Kataoka Kaori, Yasuda Toshihiro, Fujihara Junko, Toga Tomoko, Ono Rei-Ichiro, Otsuka Yosuke, Ueki Misuzu, Iida Reiko, Sano Rie, Nakajima Tamiko, Kominato Yoshihiko, Kato Hideaki, Takeshita Haruo
Abstract excerpt
Five SNPs in the human DNase II gene have been reported to be associated with rheumatoid arthritis (RA). Genotype and haplotype analysis of 14 SNPs, nine SNPs of which reported in the NCBI dbSNP database in addition to these five SNPs, was performed in healthy subjects. The enzymatic activities of the amino acid substituted DNase II corresponding to each SNP and serum DNase II in healthy Japanese, and promoter...
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