Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Why imatinib remains an exception of cancer research

28 Sept 2012

Abstract excerpt

The archetype driving the drug targeting approach to cancer therapy is the success of imatinib against chronic phase chronic myeloid leukemia (CML-CP). Molecular targeting success of this magnitude has yet to be repeated for most solid tumors. To answer why imatinib remains an exception of cancer research, we summarize key features and patterns of evolution that contrast CML-CP from prostate cancer, an example of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Myeloid Leukemia Treatments
Share to Chronic Lymphocytic Leukemia Research
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23018746
DOI: 10.1002/jcp.24233

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Why imatinib remains an exception of cancer researchPMID 23018746Read ↗

Stochastically Emergent Tumors offer in vivo whole genome interrogation of cancer evolution from non-malignant precursorsSemantic proximity Read ↗

Nothing in cancer makes sense except….Semantic proximity Read ↗

Analysis of cellular models of clonal evolution reveals co-evolution of imatinib and HSP90 inhibitor resistancesSemantic proximity Read ↗

Clonal evolution in cancer.Semantic proximity Read ↗

The chronic myeloid leukemia stem cell: stemming the tide of persistenceSemantic proximity Read ↗

Cancer: the evolved consequence of a destabilized genomeSemantic proximity Read ↗

In defense of the somatic mutation theory of cancer.Semantic proximity Read ↗

Concise Review: Cancer Cells Escape from Oncogene Addiction: Understanding the Mechanisms Behind Treatment Failure for More Effective TargetingSemantic proximity Read ↗

Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia.Semantic proximity Read ↗

Clonal selection and asymmetric distribution of human leukemia in murine xenografts revealed by cellular barcodingSemantic proximity Read ↗

Spectrum of somatic mutation dynamics in chronic myeloid leukemia following tyrosine kinase inhibitor therapySemantic proximity Read ↗

Prolonged indolent clinical course in a high-risk chronic phase-CML patient without cytogenetic or molecular response: a case challenging established response paradigmsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.