Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Influenza PB1-F2 Inhibits Avian MAVS Signaling

7 Apr 2020

Abstract excerpt

RIG-I plays an essential role in the duck innate immune response to influenza infection. RIG-I engages the critical adaptor protein mitochondrial antiviral signaling (MAVS) to activate the downstream signaling pathway. The influenza A virus non-structural protein PB1-F2 interacts with MAVS in human cells to inhibit interferon production. As duck and human MAVS share only 28% amino acid similarity, it is not known...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Response and Inflammation
Share to Influenza Virus Research Studies
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32272772
DOI: 10.3390/v12040409

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influenza PB1-F2 Inhibits Avian MAVS SignalingPMID 32272772Read ↗

Avian Influenza NS1 Proteins Inhibit Human, but Not Duck, RIG-I Ubiquitination and Interferon SignalingSemantic proximity Read ↗

Chicken Cells Sense Influenza A Virus Infection through MDA5 and CARDIF Signaling Involving LGP2Semantic proximity Read ↗

Characterization of Chicken Mda5 Activity: Regulation of IFN-β in the Absence of RIG-I FunctionalitySemantic proximity Read ↗

Virus subtype-specific suppression of MAVS aggregation and activation by PB1-F2 protein of influenza A (H7N9) virusSemantic proximity Read ↗

Interactions between the Influenza A Virus RNA Polymerase Components and Retinoic Acid-Inducible Gene ISemantic proximity Read ↗

Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate ImmunitySemantic proximity Read ↗

Innate sensing of viruses by pattern recognition receptors in birdsSemantic proximity Read ↗

Identification of key host genes for influenza A virus in avian cells using a genome-wide CRISPR-Cas9 screenSemantic proximity Read ↗

Human Metapneumovirus M2-2 Protein Inhibits Innate Cellular Signaling by Targeting MAVSSemantic proximity Read ↗

Quantitative Proteomic Analysis of the Influenza A Virus Nonstructural Proteins NS1 and NS2 during Natural Cell Infection Identifies PACT as an NS1 Target Protein and Antiviral Host FactorSemantic proximity Read ↗

SARS‐CoV‐2 modulation of RIG‐I‐MAVS signaling: Potential mechanisms of impairment on host antiviral immunity and therapeutic approachesSemantic proximity Read ↗

The NS1 protein of influenza B virus binds 5’-triphosphorylated dsRNA to suppress RIG-I activation and the host antiviral responseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.