Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Peptide binding specificities of HLA-B5701 and B5801.

Science China. Life sciences - 1 Sept 2012

Zhang YaLan, Mei Hu, Wang Qing, Xie JiangAn, Lv Juan, Pan XianChao, Tan Wen

Abstract excerpt

Recently, genome wide association studies showed that there is a strong association between abacavir-induced serious, idiosyncratic, adverse drug reactions (ADRs) and human leukocyte antigen-B*5701 (HLA-B*5701). Studies also found that abacavir-induced ADRs were seldom observed in patients carrying the HLA-B*5801 subtype. HLA-B*5801 of the same serotype (B17) as B*5701 differs by only 4 amino acids from B*5701....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding, Competitive
Share to Dideoxynucleosides
Share to Drug Hypersensitivity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-B Antigens

Share to Hydrophobic and Hydrophilic Interactions

Share to Quantitative Structure-Activity Relationship

Share to Reverse Transcriptase Inhibitors

Share to Support Vector Machine

Source

Identifiers

PMID: 23015131
DOI: 10.1007/s11427-012-4374-z

Genes

MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Peptide binding specificities of HLA-B*5701 and B*5801.PMID 23015131Read ↗

Adverse drug reactions triggered by the common HLA-B*57:01 variant: a molecular docking studySemantic proximity Read ↗

Association of HLA-B*5701 genotypes and abacavir-induced hypersensitivity reaction: a systematic review and meta-analysis.Semantic proximity Read ↗

HLA-B*5701 typing by sequence-specific amplification: validation and comparison with sequence-based typing.Semantic proximity Read ↗

Activation of CD8+ T-Cell with abacavir and HLA-B*57:01 binding peptides and elimination of T-Cell responses through chemical modificationSemantic proximity Read ↗

First large, multicenter, open-label study utilizing HLA-B*5701 screening for abacavir hypersensitivity in North America.Semantic proximity Read ↗

Studies on abacavir-induced hypersensitivity reaction: a successful example of translation of pharmacogenetics to personalized medicineSemantic proximity Read ↗

Clinical pharmacogenetics implementation consortium guidelines for HLA-B genotype and abacavir dosing.Semantic proximity Read ↗

The Pharmacogenomic HLA Biomarker Associated to Adverse Abacavir Reactions: Comparative Analysis of Different Genotyping MethodsSemantic proximity Read ↗

HLA-B*5701 screening for hypersensitivity to abacavir.Semantic proximity Read ↗

Molecular docking to investigate HLA-associated idiosyncratic drug reactionsSemantic proximity Read ↗

QSAR study on MHC class I a alleles based on the novel parameters of amino acids.Semantic proximity Read ↗

[HLA-B*5701 and hypersensitivity reactions to abacavir. Study methods and clinical relevance].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.