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Article

Rigidifying acyl carrier protein domain in iterative type I PKS CalE8 does not affect its function.

Biophysical journal - 5 Sept 2012

Lim Jackwee, Sun Huihua, Fan Jing-Song, Hameed Iman Fahim, Lescar Julien, Liang Zhao-Xun, Yang Daiwen

Abstract excerpt

Acyl carrier protein (ACP) domains shuttle acyl intermediates among the catalytic domains of multidomain type I fatty acid synthase and polyketide synthase (PKS) systems. It is believed that the unique function of ACPs is associated with their dynamic property, but it remains to be fully elucidated what type of protein dynamics is critical for the shuttling domain. Using NMR techniques, we found that the ACP...

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Identifiers

PMID: 23009853
DOI: 10.1016/j.bpj.2012.08.006
PMCID: PMC3433619

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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