Article
Expression of STM4467-encoded arginine deiminase controlled by the STM4463 regulator contributes to Salmonella enterica serovar Typhimurium virulence.
Infection and immunity - 1 Dec 2012
Choi Younho, Choi Jeongjoon, Groisman Eduardo A, Kang Dong-Hyun, Shin Dongwoo, Ryu Sangryeol
Abstract excerpt
Arginine deiminase (ADI), carbamate kinase (CK), and ornithine transcarbamoylase (OTC) constitute the ADI system. In addition to metabolic functions, the ADI system has been implicated in the virulence of certain pathogens. The pathogenic intracellular bacterium Salmonella enterica serovar Typhimurium possesses the STM4467, STM4466, and STM4465 genes, which are predicted to encode ADI, CK, and OTC, respectively....
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