Article
Comparative proteomic analysis of Salmonella enterica serovar Typhimurium ppGpp-deficient mutant to identify a novel virulence protein required for intracellular survival in macrophages.
BMC microbiology - 21 Dec 2010
Haneda Takeshi, Sugimoto Mariko, Yoshida-Ohta Yukie, Kodera Yoshio, Oh-Ishi Masamichi, Maeda Tadakazu, Shimizu-Izumi Satomi, Miki Tsuyoshi, Kumagai Yoshinori, Danbara Hirofumi, Okada Nobuhiko
Abstract excerpt
BACKGROUND: The global ppGpp-mediated stringent response in pathogenic bacteria plays an important role in the pathogenesis of bacterial infections. In Salmonella enterica serovar Typhimurium (S. Typhimurium), several genes, including virulence genes, are regulated by ppGpp when bacteria are under the stringent response. To understand the control of virulence genes by ppGpp in S. Typhimurium, agarose...
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