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Article

IgM+IgD+CD27+ B cells are markedly reduced in IRAK-4-, MyD88-, and TIRAP- but not UNC-93B-deficient patients.

Blood - 13 Dec 2012

Weller Sandra, Bonnet Mélanie, Delagreverie Héloïse, Israel Laura, Chrabieh Maya, Maródi László, Rodriguez-Gallego Carlos, Garty Ben-Zion, Roifman Chaim, Issekutz Andrew C, Zitnik Simona Eva, Hoarau Cyrille, Camcioglu Yildiz, Vasconcelos Júlia, Rodrigo Carlos, Arkwright Peter D, Cerutti Andrea, Meffre Eric, Zhang Shen-Ying, Alcais Alexandre, Puel Anne, Casanova Jean-Laurent, Picard Capucine, Weill Jean-Claude, Reynaud Claude-Agnès

Abstract excerpt

We studied the distribution of peripheral B-cell subsets in patients deficient for key factors of the TLR-signaling pathways (MyD88, TIRAP/MAL, IL-1 receptor-associated kinase 4 [IRAK-4], TLR3, UNC-93B, TRIF). All TLRs, except TLR3, which signals through the TRIF adaptor, require MyD88 and IRAK-4 to mediate their function. TLR4 and the TLR2 heterodimers (with TLR1, TLR6, and possibly TLR10) require in addition...

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Identifiers

PMID: 23002119
DOI: 10.1182/blood-2012-07-440776
PMCID: PMC3525023

Genes

TIRAP
TLR3
TLR10
TLR9
MAL
TLR1
TLR2
TLR4
TLR6
TLR7
TLR8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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