Article
Blocks in the pseudouridimycin pathway unlock hidden metabolites in the Streptomyces producer strain.
Scientific reports - 12 Mar 2021
Iorio Marianna, Davatgarbenam Sahar, Serina Stefania, Criscenzo Paolo, Zdouc Mitja M, Simone Matteo, Maffioli Sonia I, Ebright Richard H, Donadio Stefano, Sosio Margherita
Abstract excerpt
We report a metabolomic analysis of Streptomyces sp. ID38640, a soil isolate that produces the bacterial RNA polymerase inhibitor pseudouridimycin. The analysis was performed on the wild type, on three newly constructed and seven previously reported mutant strains disabled in different genes required for pseudouridimycin biosynthesis. The results indicate that Streptomyces sp. ID38640 is able to produce, in...
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