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Article

Influence of a three-dimensional, microarray environment on human cell culture in drug screening systems.

Biomaterials - 1 Dec 2012

Meli Luciana, Jordan Eric T, Clark Douglas S, Linhardt Robert J, Dordick Jonathan S

Abstract excerpt

We have used a modified 3D cellular microarray platform for the high-throughput analysis of growth, cytotoxicity, and protein expression profile of a human hepatocellular carcinoma cell line, HepG2, in alginate. The results obtained were compared to analogous studies in 2D and 3D environments at the microtiter scale. The antiproliferative effects of four drugs, tamoxifen, 5-fluorouracil, doxorubicin, and...

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Identifiers

PMID: 22998815
DOI: 10.1016/j.biomaterials.2012.08.065
PMCID: PMC3517800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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