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Article

The pluripotent renal stem cell regulator SIX2 is activated in renal neoplasms and influences cellular proliferation and migration.

Human pathology - 1 Mar 2013

Senanayake Upeka, Koller Karin, Pichler Martin, Leuschner Ivo, Strohmaier Heimo, Hadler Ulrike, Das Suman, Hoefler Gerald, Guertl Barbara

Abstract excerpt

Embryonal renal mesenchyme contains pluripotent progenitor cells characterized by expression of SIX2, which suppresses cellular differentiation. Additionally hypomethylation of the promotor region in renal neoplasms indicates a role of SIX2 in tumorigenesis. This study focuses therefore on the investigation of SIX2 in different renal neoplasms and the mode and consequences of SIX2 activation. Expression of SIX2...

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Source

Identifiers

PMID: 22995329
DOI: 10.1016/j.humpath.2012.05.021

Genes

SIX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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