Article

Robust osteogenic efficacy of 2a-heteroarylalkyl vitamin D analogue AH-1 in VDR(R270L) hereditary vitamin D-dependent rickets model rats

2022-05-31

Abstract excerpt

Active vitamin D form 1a,25-dihydroxtvitamin D3 (1,25(OH)2D3) plays pivotal roles in calcium homeostasis and osteogenesis via its transcription regulation effect via binding to vitamin D receptor (VDR). Mutated VDR often causes hereditary vitamin D-dependent rickets (VDDR) type II, and patients with VDDR-II are hardly responsive to physiological doses of 1,25(OH)2D3. Current therapeutic approaches, including high...

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Literature Corpus work: 3c10b925-4faa-51a9-a8b1-19094aedeeb7
DOI: 10.21203/rs.3.rs-1544589/v1

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