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Article

Identification of the cysteine residue responsible for disulfide linkage of Na+ channel α and β2 subunits.

The Journal of biological chemistry - 9 Nov 2012

Chen Chunling, Calhoun Jeffrey D, Zhang Yanqing, Lopez-Santiago Luis, Zhou Ningna, Davis Tigwa H, Salzer James L, Isom Lori L

Abstract excerpt

Voltage-gated Na(+) channels in the brain are composed of a single pore-forming α subunit, one non-covalently linked β subunit (β1 or β3), and one disulfide-linked β subunit (β2 or β4). The final step in Na(+) channel biosynthesis in central neurons is concomitant α-β2 disulfide linkage and insertion into the plasma membrane. Consistent with this, Scn2b (encoding β2) null mice have reduced Na(+) channel cell...

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Identifiers

PMID: 22992729
DOI: 10.1074/jbc.M112.397646
PMCID: PMC3493947

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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