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Article

Paucity of IL-21-producing CD4(+) T cells is associated with Th17 cell depletion in SIV infection of rhesus macaques.

Blood - 8 Nov 2012

Micci Luca, Cervasi Barbara, Ende Zachary S, Iriele Robin I, Reyes-Aviles Elane, Vinton Carol, Else James, Silvestri Guido, Ansari Aftab A, Villinger Francois, Pahwa Savita, Estes Jacob D, Brenchley Jason M, Paiardini Mirko

Abstract excerpt

IL-21 regulates Th17 cell homeostasis, enhances the differentiation of memory B cells and antibody-secreting plasma cells, and promotes the maintenance of CD8(+) T-cell responses. In this study, we investigated the phenotype, function, and frequency of blood and intestinal IL-21-producing cells in nonhuman primates that are hosts of progressive (rhesus macaques [RMs]) and nonprogressive (sooty mangabeys [SMs])...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22990011
DOI: 10.1182/blood-2012-04-420240
PMCID: PMC3496953

Genes

CCR6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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