Article
Analyzing Association Mapping in Pedigree-Based GWAS Using a Penalized Multitrait Mixed Model.
Genetic epidemiology - 1 Jul 2016
Liu Jin, Yang Can, Shi Xingjie, Li Cong, Huang Jian, Zhao Hongyu, Ma Shuangge
Abstract excerpt
Genome-wide association studies (GWAS) have led to the identification of many genetic variants associated with complex diseases in the past 10 years. Penalization methods, with significant numerical and statistical advantages, have been extensively adopted in analyzing GWAS. This study has been partly motivated by the analysis of Genetic Analysis Workshop (GAW) 18 data, which have two notable characteristics....
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