Study of HLA segregation in 479 thalassemic families.

doi:10.1111/j.1399-0039.1992.tb01908.x

Back to search

Article

Study of HLA segregation in 479 thalassemic families.

Tissue antigens - 1 Feb 1992

Contu L, Arras M, Mulargia M, La Nasa G, Carcassi C, Leone A L, Ledda A, Goddi F

Abstract excerpt

479 families, each with a proband affected by homozygous beta-thalassemia, were typed for HLA. 224 families with a total of 1020 members were typed for the HLA-A, B, C, DR and DQ loci and 255 families with 1046 family members, were typed for the HLA-A, B, and C loci. Altogether, 896 A, B, C, DR a...

Topics

Alleles
Female
Gene Frequency
Genetic Linkage
Genotype
HLA Antigens
HLA-A Antigens
HLA-B Antigens
HLA-C Antigens
HLA-DQ Antigens
HLA-DR Antigens
Haplotypes
Homozygote

Humans

Male

Phenotype

Sex Ratio

Statistics as Topic

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

Study of HLA segregation in 479 thalassemic families.PMID 1574799Read

Lack of preferential transmission of diabetic HLA alleles by healthy parents to offspring in Spanish diabetic families.Semantic proximity Read

Testing for segregation distortion in the HLA complex.Semantic proximity Read

The thalassemia syndromes: molecular characterization in the Spanish population.Semantic proximity Read

Genetic modifying factors in beta-thalassemia.Semantic proximity Read

The population genetics and dynamics of the thalassemias.Semantic proximity Read

Molecular genetics of HLA.Semantic proximity Read

β-thalassemia distribution in the old world: a historical standpoint of an ancient diseaseSemantic proximity Read

[Association of hemoglobinopathy and alpha thalassemia. Study of 45 patients].Semantic proximity Read