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Article

Kruppel-like factor 2 modulates CCR5 expression and susceptibility to HIV-1 infection.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2012

Richardson Max W, Jadlowsky Julie, Didigu Chuka A, Doms Robert W, Riley James L

Abstract excerpt

CCR5, a cell surface molecule critical for the transmission and spread of HIV-1, is dynamically regulated during T cell activation and differentiation. The molecular mechanism linking T cell activation to modulation of CCR5 expression remains undefined. Kruppel-like factor 2 (KLF2) is a transcrip...

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Source

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Identifiers

PMID: 22988032
DOI: 10.4049/jimmunol.1201431
PMCID: PMC3466370

Genes

CCR5
KLF2
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22988032-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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