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Article

Genetic polymorphism of interferon regulatory factor 5 (IRF5) correlates with allograft acute rejection of liver transplantation.

PloS one - 1 Jan 2014

Yu Xiaobo, Wei Bajin, Dai Yifan, Zhang Min, Wu Jian, Xu Xiao, Jiang Guoping, Zheng Shusen, Zhou Lin

Abstract excerpt

BACKGROUND: Although liver transplantation is one of the most efficient curative therapies of end stage liver diseases, recipients may suffer liver graft loss opst-operation. IRF-5, a member of Interferon Regulatory Factors, functions as a key regulator in TLR4 cascade, and is capable of inducing inflammatory cytokines. Although TLR4 has been proved to contribute to acute allograft rejection, including after...

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Identifiers

PMID: 24788560
DOI: 10.1371/journal.pone.0094426
PMCID: PMC4005731

Genes

TLR4

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