Article
Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD.
Human genetics - 1 Jan 2013
Hansel Nadia N, Ruczinski Ingo, Rafaels Nicholas, Sin Don D, Daley Denise, Malinina Alla, Huang Lili, Sandford Andrew, Murray Tanda, Kim Yoonhee, Vergara Candelaria, Heckbert Susan R, Psaty Bruce M, Li Guo, Elliott W Mark, Aminuddin Farzian, Dupuis Josée, O'Connor George T, Doheny Kimberly, Scott Alan F, Boezen H Marike, Postma Dirkje S, Smolonska Joanna, Zanen Pieter, Mohamed Hoesein Firdaus A, de Koning Harry J, Crystal Ronald G, Tanaka Toshiko, Ferrucci Luigi, Silverman Edwin, Wan Emily, Vestbo Jorgen, Lomas David A, Connett John, Wise Robert A, Neptune Enid R, Mathias Rasika A, Paré Peter D, Beaty Terri H, Barnes Kathleen C
Abstract excerpt
Accelerated lung function decline is a key COPD phenotype; however, its genetic control remains largely unknown. We performed a genome-wide association study using the Illumina Human660W-Quad v.1_A BeadChip. Generalized estimation equations were used to assess genetic contributions to lung functi...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.