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Article

The prothrombotic phenotypes in familial protein C deficiency are differentiated by computational modeling of thrombin generation.

PloS one - 1 Jan 2012

Brummel-Ziedins Kathleen E, Orfeo Thomas, Callas Peter W, Gissel Matthew, Mann Kenneth G, Bovill Edwin G

Abstract excerpt

The underlying cause of thrombosis in a large protein C (PC) deficient Vermont kindred appears to be multicausal and not explained by PC deficiency alone. We evaluated the contribution of coagulation factors to thrombin generation in this population utilizing a mathematical model that incorporate...

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Identifiers

PMID: 22984498
DOI: 10.1371/journal.pone.0044378
PMCID: PMC3440432

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22984498-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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