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Article

Endoplasmic reticulum stress induces Wfs1 gene expression in pancreatic β-cells via transcriptional activation

1 Jul 2005

Abstract excerpt

OBJECTIVE: The WFS1 gene encodes an endoplasmic reticulum (ER) membrane-embedded protein. Homozygous WFS1 gene mutations cause Wolfram syndrome, characterized by insulin-deficient diabetes mellitus and optic atropy. Pancreatic beta-cells are selectively lost from the patient's islets. ER localization suggests that WFS1 protein has physiological functions in membrane trafficking, secretion, processing and/or...

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Share to Autophagy in Disease and Therapy
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Identifiers

PMID: 15994758
DOI: 10.1530/eje.1.01945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Endoplasmic reticulum stress induces Wfs1 gene expression in pancreatic β-cells via transcriptional activationPMID 15994758Read ↗

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