Article
A mutation in endothelin-B receptor gene causes myenteric aganglionosis and coat color spotting in rats.
DNA research : an international journal for rapid publication of reports on genes and genomes - 30 Apr 1996
Kunieda T, Kumagai T, Tsuji T, Ozaki T, Karaki H, Ikadai H
Abstract excerpt
Congenital aganglionosis rat (AR) is a mutant with an autosomal recessive gene (sl), which shows megacolon caused by the absence of myenteric ganglion cells and white coat-color with a small pigmented spot on the head. Recently, targeted disruption of the endothelin-B (ETB) receptor gene (EDNRB)...
Topics
- Animals
- Base Sequence
- Codon, Terminator
- Hair
- Hirschsprung Disease
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- RNA Splicing
- Rats
- Rats, Mutant Strains
- Receptor, Endothelin B
- Receptors, Endothelin
- Repetitive Sequences, Nucleic Acid
- Sequence Analysis, DNA
- Sequence Deletion
- Transcription, Genetic