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Article

A mutation in endothelin-B receptor gene causes myenteric aganglionosis and coat color spotting in rats.

DNA research : an international journal for rapid publication of reports on genes and genomes - 30 Apr 1996

Kunieda T, Kumagai T, Tsuji T, Ozaki T, Karaki H, Ikadai H

Abstract excerpt

Congenital aganglionosis rat (AR) is a mutant with an autosomal recessive gene (sl), which shows megacolon caused by the absence of myenteric ganglion cells and white coat-color with a small pigmented spot on the head. Recently, targeted disruption of the endothelin-B (ETB) receptor gene (EDNRB) in the mouse has been reported to cause aganglionic megacolon and coat color spotting resembling the phenotypes of the...

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Source

Identifiers

PMID: 8804863
DOI: 10.1093/dnares/3.2.101

Genes

EDNRB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A mutation in endothelin-B receptor gene causes myenteric aganglionosis and coat color spotting in rats.PMID 8804863Read ↗

Null mutation of endothelin receptor type B gene in spotting lethal rats causes aganglionic megacolon and white coat color.Semantic proximity Read ↗

Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice.Semantic proximity Read ↗

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