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Article

IDH1 mutations disrupt blood, brain, and barriers.

Cancer cell - 11 Sept 2012

Shih Alan H, Levine Ross L

Abstract excerpt

The first two murine models of IDH1(R132H) mutation provide mechanistic insights into transformation. In hematopoietic cells, inhibition of TET2 and histone demethylases leads to epigenetic alterations and accumulation of hematopoietic precursors. In the central nervous system, inhibition of coll...

Read the complete abstract on PubMed

Topics

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Share to Isocitrate Dehydrogenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

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Source

Identifiers

PMID: 22975371
DOI: 10.1016/j.ccr.2012.08.022

Genes

IDH1
TET2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22975371-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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