An assay to detect in vivo Y chromosome loss in Drosophila wing disc cells.

doi:10.1534/g3.112.002899

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Article

An assay to detect in vivo Y chromosome loss in Drosophila wing disc cells.

G3 (Bethesda, Md.) - 1 Sept 2012

Szabad Janos, Bellen Hugo J, Venken Koen J T

Abstract excerpt

Loss of the Y chromosome in Drosophila has no impact on cell viability and therefore allows us to assay the impact of environmental agents and genetic alterations on chromosomal loss. To detect in vivo chromosome loss in cells of the developing Drosophila wing primordia, we first engineered a Y chromosome with an attP docking site. By making use of the ΦC31 integrase system, we site-specifically integrated a...

Topics

Animals
Animals, Genetically Modified
Carrier Proteins
Chromosome Deletion
Drosophila
Drosophila Proteins
Genomic Instability
Male
Mosaicism
Phenotype
Wings, Animal
Y Chromosome

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Identifiers

PMID: 22973547
DOI: 10.1534/g3.112.002899
PMCID: PMC3429924

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