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Incorporation of Host Complement Regulatory Proteins into Newcastle Disease Virus Enhances Complement Evasion

13 Sept 2012

Abstract excerpt

Newcastle disease virus (NDV), an avian paramyxovirus, is inherently tumor selective and is currently being considered as a clinical oncolytic virus and vaccine vector. In this study, we analyzed the effect of complement on the neutralization of NDV purified from embryonated chicken eggs, a common source for virus production. Fresh normal human serum (NHS) neutralized NDV by multiple pathways of complement...

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PMID: 22973037
DOI: 10.1128/jvi.00886-12

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