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Article

Some Novel Insights on HPV16 Related Cervical Cancer Pathogenesis Based on Analyses of LCR Methylation, Viral Load, E7 and E2/E4 Expressions

6 Sept 2012

Abstract excerpt

This study was undertaken to decipher the interdependent roles of (i) methylation within E2 binding site I and II (E2BS-I/II) and replication origin (nt 7862) in the long control region (LCR), (ii) expression of viral oncogene E7, (iii) expression of the transcript (E7-E1/E4) that encodes E2 repressor protein and (iv) viral load, in human papillomavirus 16 (HPV16) related cervical cancer (CaCx) pathogenesis. The...

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Cancer-related Molecular Pathways
Cervical Cancer and HPV Research
Genital Health and Disease

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22970286
DOI: 10.1371/journal.pone.0044678

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