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High-fat or ethinyl-oestradiol intake during pregnancy increases mammary cancer risk in several generations of offspring

11 Sept 2012

Abstract excerpt

Maternal exposures to environmental factors during pregnancy influence the risk of many chronic adult-onset diseases in the offspring. Here we investigate whether feeding pregnant rats a high-fat (HF)- or ethinyl-oestradiol (EE2)-supplemented diet affects carcinogen-induced mammary cancer risk in daughters, granddaughters and great-granddaughters. We show that mammary tumourigenesis is higher in daughters and...

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PMID: 22968699
DOI: 10.1038/ncomms2058

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