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Article

Interaction between genetic susceptibility and early-life environmental exposure determines tumor-suppressor-gene penetrance.

Proceedings of the National Academy of Sciences of the United States of America - 14 Jun 2005

Cook Jennifer D, Davis Barbara J, Cai Sheng-Li, Barrett J Carl, Conti Claudio J, Walker Cheryl Lyn

Abstract excerpt

Gene-environment interactions are important determinants of cancer risk. Traditionally, gene-environment interactions are thought to contribute to tumor-suppressor-gene penetrance by facilitating or inhibiting the acquisition of additional somatic mutations required for tumorigenesis. Here, we de...

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Identifiers

PMID: 15937110
DOI: 10.1073/pnas.0503218102
PMCID: PMC1150843

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15937110-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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