Article
PROFILing non-small-cell lung cancer patients for treatment with crizotinib according to anaplastic lymphoma kinase abnormalities: translating science into medicine.
Expert opinion on pharmacotherapy - 1 Apr 2013
Pilotto Sara, Peretti Umberto, Novello Silvia, Rossi Giulio, Milella Michele, Giaj Levra Matteo, Ciuffreda Ludovica, Massari Francesco, Brunelli Matteo, Tortora Giampaolo, Bria Emilio
Abstract excerpt
INTRODUCTION: In the recent years, the growing attention to the molecular background of non-small-cell lung cancer (NSCLC) led to the identification of different molecular subtypes according to genetic abnormalities driving the disease development and progression. Whereas the addicted pathways were successfully inhibited (such as the mutant epidermal growth factor receptor), clinicians have witnessed a dramatic...
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