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Article

Hedgehog–GLI Signaling Inhibition Suppresses Tumor Growth in Squamous Lung Cancer

15 Jan 2014

Abstract excerpt

PURPOSE: Lung squamous cell carcinoma (LSCC) currently lacks effective targeted therapies. Previous studies reported overexpression of Hedgehog (HH)-GLI signaling components in LSCC. However, they addressed neither the tumor heterogeneity nor the requirement for HH-GLI signaling. Here, we investigated the role of HH-GLI signaling in LSCC, and studied the therapeutic potential of HH-GLI suppression. EXPERIMENTAL...

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PMID: 24423612
DOI: 10.1158/1078-0432.ccr-13-2195

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