Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

What Gene Mutations Affect Serotonin in Mice?

ACS chemical neuroscience - 17 May 2017

Tenpenny Richard C, Commons Kathryn G

Abstract excerpt

Although serotonin neurotransmission has been implicated in several neurodevelopmental and psychological disorders, the factors that drive dysfunction of the serotonin system are poorly understood. Current research regarding the serotonin system revolves around its dysfunction in neuropsychiatric disorders, but there is no database collating genetic mutations that result in serotonin abnormalities. To bridge this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Gene Expression
Share to Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Neurons

Share to Serotonin

Source

Open in PubMed Open full text

Identifiers

PMID: 28418237
DOI: 10.1021/acschemneuro.6b00441
PMCID: PMC5493142

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

What Gene Mutations Affect Serotonin in Mice?PMID 28418237Read ↗

New lessons from knockout mice: The role of serotonin during development and its possible contribution to the origins of neuropsychiatric disorders.Semantic proximity Read ↗

[Genetic models to understand how serotonin acts during development].Semantic proximity Read ↗

Ontogeny of brain and blood serotonin levels in 5-HT receptor knockout mice: potential relevance to the neurobiology of autism.Semantic proximity Read ↗

Mutations in monoamine oxidase (MAO) genes in mice lead to hypersensitivity to serotonin-enhancing drugs: implications for drug side effects in humans.Semantic proximity Read ↗

Targeting the murine serotonin transporter: insights into human neurobiology.Semantic proximity Read ↗

Genetic Models of Serotonin (5‐HT) Depletion: What do They Tell Us About the Developmental Role of 5‐HT?Semantic proximity Read ↗

Inactivation of 5HT transport in mice: modeling altered 5HT homeostasis implicated in emotional dysfunction, affective disorders, and somatic syndromes.Semantic proximity Read ↗

Mutational analysis of the serotonergic system: recent findings using knockout mice.Semantic proximity Read ↗

Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression.Semantic proximity Read ↗

Biochemical, behavioral, physiologic, and neurodevelopmental changes in mice deficient in monoamine oxidase A or B.Semantic proximity Read ↗

Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants.Semantic proximity Read ↗

Serotonin (5-HT) in the regulation of depression-related emotionality: insight from 5-HT transporter and tryptophan hydroxylase-2 knockout mouse models.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.