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Article

Analysis of the Role of Igf2 in Adrenal Tumour Development in Transgenic Mouse Models

28 Aug 2012

Abstract excerpt

Adrenal cortical carcinomas (ACC) are rare but aggressive tumours associated with poor prognosis. The two most frequent alterations in ACC in patients are overexpression of the growth factor IGF2 and constitutive activation of Wnt/β-catenin signalling. Using a transgenic mouse model, we have previously shown that constitutive active β-catenin is a bona fide adrenal oncogene. However, although all these mice...

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Share to Adrenal and Paraganglionic Tumors
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PMID: 22952916
DOI: 10.1371/journal.pone.0044171

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