Article
Progression to adrenocortical tumorigenesis in mice and humans through insulin-like growth factor 2 and β-catenin.
The American journal of pathology - 1 Sept 2012
Heaton Joanne H, Wood Michelle A, Kim Alex C, Lima Lorena O, Barlaskar Ferdous M, Almeida Madson Q, Fragoso Maria C B V, Kuick Rork, Lerario Antonio M, Simon Derek P, Soares Ibere C, Starnes Elisabeth, Thomas Dafydd G, Latronico Ana C, Giordano Thomas J, Hammer Gary D
Abstract excerpt
Dysregulation of the WNT and insulin-like growth factor 2 (IGF2) signaling pathways has been implicated in sporadic and syndromic forms of adrenocortical carcinoma (ACC). Abnormal β-catenin staining and CTNNB1 mutations are reported to be common in both adrenocortical adenoma and ACC, whereas elevated IGF2 expression is associated primarily with ACC. To better understand the contribution of these pathways in the...
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