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Article

Interferon gamma and sonic hedgehog signaling are required to dysregulate murine neural stem/precursor cells.

PloS one - 1 Jan 2012

Walter Janine, Hartung Hans-Peter, Dihné Marcel

Abstract excerpt

BACKGROUND: The pro-inflammatory cytokine interferon gamma (IFNγ), a key player in various neurological diseases, was recently shown to induce a dysregulated phenotype in neural stem/precursor cells (NSPCs) that is characterized by the simultaneous expression of glial and neuronal markers and irregular electrophysiological properties. Thus far, the mechanisms of this phenomenon have remained unclear....

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Identifiers

PMID: 22952668
DOI: 10.1371/journal.pone.0043338
PMCID: PMC3430684

Genes

SHH

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