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Article

Ccdc94 protects cells from ionizing radiation by inhibiting the expression of p53.

PLoS genetics - 1 Jan 2012

Sorrells Shelly, Carbonneau Seth, Harrington Erik, Chen Aye T, Hast Bridgid, Milash Brett, Pyati Ujwal, Major Michael B, Zhou Yi, Zon Leonard I, Stewart Rodney A, Look A Thomas, Jette Cicely

Abstract excerpt

DNA double-strand breaks (DSBs) represent one of the most deleterious forms of DNA damage to a cell. In cancer therapy, induction of cell death by DNA DSBs by ionizing radiation (IR) and certain chemotherapies is thought to mediate the successful elimination of cancer cells. However, cancer cells...

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Identifiers

PMID: 22952453
DOI: 10.1371/journal.pgen.1002922
PMCID: PMC3431329

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-22952453-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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