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Article

Genome instability: does genetic diversity amplification drive tumorigenesis?

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Nov 2012

Lane Andrew B, Clarke Duncan J

Abstract excerpt

Recent data show that catastrophic events during one cell cycle can cause massive genome damage producing viable clones with unstable genomes. This is in contrast with the traditional view that tumorigenesis requires a long-term process in which mutations gradually accumulate over decades. These...

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Identifiers

PMID: 22948965
DOI: 10.1002/bies.201200082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22948965-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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