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Article

A single residue substitution accounts for the significant difference in thermostability between two isoforms of human cytosolic creatine kinase.

Scientific reports - 16 Feb 2016

Liu Huihui, Gao Yan-Song, Chen Xiang-Jun, Chen Zhe, Zhou Hai-Meng, Yan Yong-Bin, Gong Haipeng

Abstract excerpt

Creatine kinase (CK) helps maintain homeostasis of intracellular ATP level by catalyzing the reversible phosphotransfer between ATP and phosphocreatine. In humans, there are two cytosolic CK isoforms, the muscle-type (M) and the brain-type (B), which frequently function as homodimers (hMMCK and hBBCK). Interestingly, these isoenzymes exhibit significantly different thermostabilities, despite high similarity in...

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PMID: 26879258
DOI: 10.1038/srep21191
PMCID: PMC4754747

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