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Article

Mutation of the conserved Asp122 in the linker impedes creatine kinase reactivation and refolding.

International journal of biological macromolecules - 1 Apr 2009

Liu Yan-Ming, Feng Shan, Ding Xiao-Lan, Kang Chi-Fei, Yan Yong-Bin

Abstract excerpt

Creatine kinase (CK), a key enzyme in maintaining the intracellular energetic homeostasis, contains two domains connected by a long linker. In this research,we found that the mutations of the conserved Asp122 in the linker slightly affected CK activity, structure and stability. The hydrogen bonding and the ion pair contributed 2-5 kJ/mol to the conformational stability of CK. Interestingly, the ability of CK...

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Identifiers

PMID: 19263506
DOI: 10.1016/j.ijbiomac.2008.12.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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