Article
Decreased serum antioxidant capacity in patients with Wilson disease is associated with neurological symptoms.
Journal of inherited metabolic disease - 1 May 2012
Bruha Radan, Vitek Libor, Marecek Zdenek, Pospisilova Lenka, Nevsimalova Sona, Martasek Pavel, Petrtyl Jaromir, Urbanek Petr, Jiraskova Alena, Malikova Ivana, Haluzik Martin, Ferenci Peter
Abstract excerpt
BACKGROUND & AIMS: Wilson disease (WD) is an inherited disorder of copper disposition caused by an ATP7B transporter gene mutation, leading to copper accumulation in predisposed tissues. In addition to a genetic predisposition, other factors are likely to contribute to its clinical manifestation. The aim of the study was to assess whether oxidative stress affects the phenotypic manifestation of WD. METHODS: In 56...
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