Article
The association of interleukin-16 polymorphisms with IL-16 serum levels and risk of colorectal and gastric cancer.
Carcinogenesis - 1 Feb 2009
Gao Lin-Bo, Rao Li, Wang Yan-Yun, Liang Wei-Bo, Li Cui, Xue Hui, Zhou Bin, Sun Hong, Li Yi, Lv Mei-Li, Du Xiao-Jiong, Zhang Lin
Abstract excerpt
Interleukin (IL)-16, a multifunctional cytokine, plays a fundamental role in inflammatory diseases, as well as in the development and progression of tumors. Genetic variation in the DNA sequence of the IL-16 gene may lead to altered cytokine production and/or activity, and this variation may modulate an individual's susceptibility to both colorectal cancer (CRC) and gastric cancer (GC). To test this hypothesis,...
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