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Role of aldo-keto reductases and other doxorubicin pharmacokinetic genes in doxorubicin resistance, DNA binding, and subcellular localization

31 Aug 2012

Abstract excerpt

BACKGROUND: Since proteins involved in chemotherapy drug pharmacokinetics and pharmacodynamics have a strong impact on the uptake, metabolism, and efflux of such drugs, they likely play critical roles in resistance to chemotherapy drugs in cancer patients. METHODS: To investigate this hypothesis, we conducted a whole genome microarray study to identify difference in the expression of genes between isogenic...

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Share to Aldose Reductase and Taurine
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22938713
DOI: 10.1186/1471-2407-12-381

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