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Long non-coding RNAs as the critical regulators of doxorubicin resistance in tumor cells

23 Aug 2021

Abstract excerpt

Resistance against conventional chemotherapeutic agents is one of the main reasons for tumor relapse and poor clinical outcomes in cancer patients. Various mechanisms are associated with drug resistance, including drug efflux, cell cycle, DNA repair and apoptosis. Doxorubicin (DOX) is a widely used first-line anti-cancer drug that functions as a DNA topoisomerase II inhibitor. However, DOX resistance has emerged...

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PMID: 34425750
DOI: 10.1186/s11658-021-00282-9

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