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Comprehensive Analysis of Transcriptomics and Genetic Alterations Identifies Potential Mechanisms Underlying Anthracycline Therapy Resistance in Breast Cancer.

Biomolecules - 8 Dec 2022

Liu Zihao, Gao Jingbo, Gu Ran, Shi Yu, Hu Hong, Liu Jianlan, Huang Jiefeng, Zhong Caineng, Zhou Wenbin, Yang Yaping, Gong Chang

Abstract excerpt

Anthracycline is a mainstay of treatment for breast cancer patients because of its antitumor activity. However, anthracycline resistance is a critical barrier in treating breast cancer. Thus, it is of great importance to uncover the molecular mechanisms underlying anthracycline resistance in breast cancer. Herein, we integrated transcriptome data, genetic alterations data, and clinical data of The Cancer Genome...

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Share to Anthracyclines
Share to Antibiotics, Antineoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Breast Neoplasms

Share to Cytochrome P450 Family 4

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Source

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Identifiers

PMID: 36551262
DOI: 10.3390/biom12121834
PMCID: PMC9775906

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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