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Article

Phylogenomic analysis of type I polyketide synthase genes in pathogenic and saprobic ascomycetes.

Proceedings of the National Academy of Sciences of the United States of America - 23 Dec 2003

Kroken Scott, Glass N Louise, Taylor John W, Yoder O C, Turgeon B Gillian

Abstract excerpt

Fungal type I polyketides (PKs) are synthesized by PK synthases (PKSs) and include well known secondary metabolites such as the anticholesterol drug lovastatin and the potent natural carcinogen aflatoxin. Other type I PKs are known to be virulence factors for some plant pathogens and pigments such as melanin. In this study, a phylogenomic approach was used to investigate the origin and diversity of fungal genes...

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Identifiers

PMID: 14676319
DOI: 10.1073/pnas.2532165100
PMCID: PMC307626

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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