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Article

FunSAV: predicting the functional effect of single amino acid variants using a two-stage random forest model.

PloS one - 1 Jan 2012

Wang Mingjun, Zhao Xing-Ming, Takemoto Kazuhiro, Xu Haisong, Li Yuan, Akutsu Tatsuya, Song Jiangning

Abstract excerpt

Single amino acid variants (SAVs) are the most abundant form of known genetic variations associated with human disease. Successful prediction of the functional impact of SAVs from sequences can thus lead to an improved understanding of the underlying mechanisms of why a SAV may be associated with certain disease. In this work, we constructed a high-quality structural dataset that contained 679 high-quality...

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Identifiers

PMID: 22937107
DOI: 10.1371/journal.pone.0043847
PMCID: PMC3427247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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