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Article

Basal vertebrates clarify the evolutionary history of ciliopathy-associated genes Tmem138 and Tmem216.

Molecular biology and evolution - 1 Jan 2013

Venkatesh Byrappa, Ravi Vydianathan, Lee Alison P, Warren Wesley C, Brenner Sydney

Abstract excerpt

Recently, Lee et al. (Lee JH, Silhavy JL, Lee JE, et al. (30 co-authors). 2012. Evolutionarily assembled cis-regulatory module at a human ciliopathy locus. Science (335:966-969.) demonstrated that mutation in either of the transmembrane protein encoding genes, TMEM138 or TMEM216, causes phenotypically indistinguishable ciliopathy. Furthermore, on the basis of the observation that their orthologs are linked in a...

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PMID: 22936720
DOI: 10.1093/molbev/mss215
PMCID: PMC3657383

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