Article
Grey, a novel mutation in the murine Lyst gene, causes the beige phenotype by skipping of exon 25.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Mar 2006
Runkel Fabian, Büssow Heinrich, Seburn Kevin L, Cox Gregory A, Ward Diane McVey, Kaplan Jerry, Franz Thomas
Abstract excerpt
The murine beige mutant phenotype and the human Chediak-Higashi syndrome are caused by mutations in the murine Lyst (lysosomal trafficking regulator) gene and the human CHS gene, respectively. In this report we have analyzed a novel murine mutant Lyst allele, called Lyst(bg-grey), that had been found in an ENU mutation screen and named grey because of the grey coat color of affected mice. The phenotype caused by...
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