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Novel replication-incompetent adenoviral B-group vectors: high vector stability and yield in PER.C6 cells

17 Jul 2006

Abstract excerpt

Adenoviral vectors based on adenovirus type 35 (rAd35) have the advantage of low natural vector immunity and induce strong, insert-specific T- and B-cell responses, making them prime-candidate vaccine carriers. However, severe vector-genome instability of E1-deleted rAd35 vectors was observed, hampering universal use. The instability of E1-deleted rAd35 vector proved to be caused by low pIX expression induced by...

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PMID: 16847108
DOI: 10.1099/vir.0.81956-0

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