Article
Cytotoxicity of superoxide dismutase 1 in cultured cells is linked to Zn2+ chelation.
PloS one - 1 Jan 2012
Johansson Ann-Sofi, Vestling Monika, Zetterström Per, Lang Lisa, Leinartaitė Lina, Karlström Mikael, Danielsson Jens, Marklund Stefan L, Oliveberg Mikael
Abstract excerpt
Neurodegeneration in protein-misfolding disease is generally assigned to toxic function of small, soluble protein aggregates. Largely, these assignments are based on observations of cultured neural cells where the suspect protein material is titrated directly into the growth medium. In the present study, we use this approach to shed light on the cytotoxic action of the metalloenzyme Cu/Zn superoxide dismutase 1...
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