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Article

Alteration of familial ALS-linked mutant SOD1 solubility with disease progression: its modulation by the proteasome and Hsp70.

Biochemical and biophysical research communications - 12 May 2006

Koyama Shingo, Arawaka Shigeki, Chang-Hong Ren, Wada Manabu, Kawanami Toru, Kurita Keiji, Kato Masaaki, Nagai Makiko, Aoki Masashi, Itoyama Yasuto, Sobue Gen, Chan Pak H, Kato Takeo

Abstract excerpt

Accumulation of misfolded Cu/Zn superoxide dismutase (SOD1) occurs in patients with a subgroup of familial amyotrophic lateral sclerosis (fALS). To identify the conversion of SOD1 from a normally soluble form to insoluble aggregates, we investigated the change of SOD1 solubility with aging in fALS-linked H46R SOD1 transgenic mice. Mutant SOD1 specifically altered to insoluble forms, which were sequentially...

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Identifiers

PMID: 16563356
DOI: 10.1016/j.bbrc.2006.02.170

Genes

SOD1
SDS

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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